Yeghishe Manucharyan has performed at the Metropolitan Opera, New York City Opera, Carnegie Hall, Avery Fisher Hall at Lincoln Center, Opera Boston, Boston Concert Opera, Minnesota Opera, San Diego Opera, Tulsa Opera, Toledo Opera, Baltimore Opera, Knoxville Opera, Tanglewood Festival, Teatro San Carlo of Naples, Italy, Wexford Festival in Ireland, Armenian National Opera as well as the New York Choral Society, Opera Orchestra of New York, Masterworks Chorale, Caramoor International Music Festival, the Dallas Symphony, Baltimore Symphony, Boston Modern Orchestra Project and Orquesta Sinfonica del Estado de Mejico. In opera he has appeared in such roles as Alfredo in La Traviata, Rodolfo in La Boheme, Cavaradossi in Tosca Lykov in Rimsky-Korsakov’s Tsar’s Bride, Shostakovich’s The Nose, Argirio in Tancredi, Armida, Gerald in Lakme, Leidcester in Mara Stuarda, Pylade in Gluck’s Iphigenie en Tauride, Don Ruiz in Maria Padilla, Don Ottavio in Don Giovanni, Rodrigo in La Donna del Lago, Ricardo in Maria di Rohan, Nadir in The Pearl Fishers, Lensky in Eugene Onegin, the Duke in Rigoletto, Tamino in Die Zauberfloete, Leicester in Maria Sturada, Arturo in I Puritani, Belmonte in Die Entführung aus dem Serail, Cassio in Otello, Count Almaviva in Il barbiere di Siviglia, Don Ramiro in La Cenerentola, Tito in La clemenza di Tito, Potosi in Donizetti’s Elizabeth, Rinuccio in Gianni Schicchi and Saro in Tigranian’s Anoush. On the concert Stage he has performed the Berlioz Requiem. Verdi Requiem, Beethoven’s Missa Solemnis and 9th Symphony, Dvorak Stabat Mater, Brucknr’s Te Deumand and Lukas Foss’ Griffelkin.